Loading...
Lck Function and Modulation: Immune Cytotoxic Response and Tumor Treatment More Than a Simple Event
Puskasu, Alex
Puskasu, Alex
Abstract
Lck, a member of the Src kinase family, is a non-receptor tyrosine kinase involved in immune cell activation, antigen recognition, tumor growth, and cytotoxic response. The enzyme has usually been linked to T lymphocyte activation upon antigen recognition. Lck activation is central to CD4, CD8, and NK activation. However, recently, it has become clearer that activating the enzyme in CD8 cells can be independent of antigen presentation and enhance the cytotoxic response. The role of Lck in NK cytotoxic function has been controversial in a similar fashion as the role of the enzyme in CAR T cells. Inhibiting tyrosine kinases has been a highly successful approach to treating hematologic malignancies. The inhibitors may be useful in treating other tumor types, and they may be useful to prevent cell exhaustion. New, more selective inhibitors have been documented, and they have shown interesting activities not only in tumor growth but in the treatment of autoimmune diseases, asthma, and graft vs. host disease. Drug repurposing and bioinformatics can aid in solving several unsolved issues about the role of Lck in cancer. In summary, the role of Lck in immune response and tumor growth is not a simple event and requires more research.
Description
Date
2024-07-24
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Research Projects
Organizational Units
Journal Issue
Keywords
Src kinases, Lck, hematologic tumors, solid tumors, T-cell cytotoxicity, NK cytotoxicity, CAR-T cell, cell proliferation, cell adhesion